If you know the heat loss coefficient of the property, you can easily calculate how much power is needed for a given indoor temperature. And if you know how much power your emitters will output at dT 50, you can work out what flow temperature they need to be at for the heat currently needed. This is essentially what the weather compensation curve does. I wrote about it here:
Room influence can be added on top of weather compensation, to add a little more heat when the house temperature is below target, or less when it’s over target.