This thread should help:
Are you aware that you’ll take a significant peformance hit with MySQL?
Performance won’t drop immediately, but rather get slower as your database grows.
If you’re not running emonCMS on a Raspberry Pi, this may not be an issue. i.e. depending on the hardware you’re running, performance may not be impacted to the same degree as it would when running emonCMS on a RasPi.